Genes, brains and lateralisation: how solid is the evidence?

If there were a dictionary of famous neurological quotes, “Nous parlons avec l'hémisphère gauche” by Paul Broca (1865) would be up there among the top hits. Broca’s realisation that the two sides of the brain are functionally distinct was a landmark observation. It was based on a rather small series of patients, but has since been confirmed in numerous studies. After localised brain injury, aphasia (language impairment) is far more likely after damage to the left side than the right side. And nowadays, we can visualise greater activation of the left side in neurologically intact people as they do language tasks in a brain scanner. There are many fascinating features of cerebral lateralisation, but I’m going to focus here on just one specific question: what do we know about genetic influences on brain asymmetry in humans? There are really two questions here: (1) how do genes lead to asymmetric brain development? (2) are there genetic variants that can account for individual variat...